Cell-free tumor DNA, CA125 and HE4 for the objective assessment of tumor burden in patients with advanced high-grade serous ovarian cancer.

Florian HeitzSotirios LakisPhilipp HarterSebastian HeikausJalid SehouliJatin TalwarRoopika MenonBeyhan AtasevenMiriam BertrandStephanie SchneiderErika MariottiMareike BommertJudith N MüllerSonia PraderFrauke LeendersAlexandra HengsbachChristian GloecknerElena Ioana BraicuLukas C HeukampAndreas du BoisJohannes M Heuckmann

Published in: PloS one (2022)

Based upon the present findings, ct-DNA assessment in patients with high-grade serous EOC might help to better determine disease burden compared to standard tumor markers. Further studies should prospectively evaluate whether this enhancement of accuracy can help to optimize management of patients with EOC.

Keyphrases

high grade
cell free
low grade
circulating tumor
computed tomography
single molecule
magnetic resonance
image quality
nucleic acid
protein kinase
positron emission tomography