Development and validation of a HPLC-UV method for methadone hydrochloride quantification in a new oral solution with preservatives to be implemented in physicochemical stability studies.
Elena Alba Álvaro-AlonsoMa Paz LorenzoIsmael Escobar RodríguezAntonio Aguilar-RosPublished in: BMC chemistry (2022)
The HPLC method has proved to be valid and reproducible for methadone quantification in a new oral solution with methylparaben and propylparaben. This assay is a rapid, simple and reliable technique that can be used in daily analysis and physicochemical stability studies.