Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immune Phenotypes.

Hanna Nebenzahl-GuimaraesArjan van LaarhovenMaha R FarhatValerie A C M Koeken Jornt J MandemakersAldert ZomerSacha A F T van HijumMihai G NeteaMegan MurrayReinout van CrevelDick van Soolingen

Published in: American journal of respiratory and critical care medicine (2017)

In this study, we identified genetic markers in convergent evolution of M. tuberculosis toward enhanced transmissibility in vivo that are associated with altered immune responses in vitro.

Keyphrases

mycobacterium tuberculosis
immune response
genome wide
pulmonary tuberculosis
escherichia coli
copy number
gene expression
emergency department
hiv aids
dna methylation
dendritic cells