Chronic aryl hydrocarbon receptor activity phenocopies smoking-induced skeletal muscle impairment.

Trace ThomeKayla MiguezAlexander J WillmsSarah K BurkeVijayendran ChandranAngela R de SouzaLiam F FitzgeraldCarolyn BagloleMaria-Eleni AnagnostouJean BourbeauR Thomas JagoeJose A MoraisYana GoddardTanja TaivassaloTerence E RyanRussell T Hepple

Published in: Journal of cachexia, sarcopenia and muscle (2021)

These results establish that chronic AHR activity, as occurs in smokers, phenocopies the atrophy, mitochondrial impairment, and neuromuscular junction degeneration caused by chronic tobacco smoke exposure.

Keyphrases

skeletal muscle
smoking cessation
drug induced
oxidative stress
type diabetes
metabolic syndrome
adipose tissue
diabetic rats