Interplay of Atherogenic Particle Number and Particle Size and the Risk of Coronary Heart Disease.
Karol M PencinaMichael J PencinaPatrick R LawlerJames C EngertLine DufresnePaul M RidkerGeorge ThanassoulisSamia MoraAllan D SnidermanPublished in: Clinical chemistry (2022)
Our analysis confirms that apoB is a strong risk factor for CHD. However, given the null association in 2 of the 3 studies, we cannot confirm that cholesterol-depleted LDL particles are substantially more atherogenic than cholesterol-replete particles. These results lend further support to routine measurement of apoB in clinical care.