The Macromolecular Femtosecond Crystallography Instrument at the Linac Coherent Light Source.
Raymond G SierraAlexander BatyukZhibin SunAndrew AquilaMark S HunterThomas J LaneMengning LiangChun Hong YoonRoberto Alonso-MoriRebecca ArmentaJean Charles CastagnaMichael HollenbeckTed O OsierMatt HayesJeff AldrichRobin CurtisJason E KoglinTheodore RendahlEvan RodriguezSergio CarbajoSerge GuilletRob PaulPhilip HartKazutaka NakaharaGabriella CariniHasan DeMirciE Han DaoBrandon M HayesYashas P RaoMatthieu CholletYiping FengFranklin D FullerChristopher KupitzTakahiro SatoMatthew H SeabergSanghoon SongTim B van DrielHasan YavasDiling ZhuAina E CohenSoichi WakatsukiSébastien BoutetPublished in: Journal of synchrotron radiation (2019)
The Macromolecular Femtosecond Crystallography (MFX) instrument at the Linac Coherent Light Source (LCLS) is the seventh and newest instrument at the world's first hard X-ray free-electron laser. It was designed with a primary focus on structural biology, employing the ultrafast pulses of X-rays from LCLS at atmospheric conditions to overcome radiation damage limitations in biological measurements. It is also capable of performing various time-resolved measurements. The MFX design consists of a versatile base system capable of supporting multiple methods, techniques and experimental endstations. The primary techniques supported are forward scattering and crystallography, with capabilities for various spectroscopic methods and time-resolved measurements. The location of the MFX instrument allows for utilization of multiplexing methods, increasing user access to LCLS by running multiple experiments simultaneously.