Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.
Victor Bodart-SantosLuiza R P de CarvalhoMariana A de GodoyAndré F BatistaLeonardo M SaraivaLuize G LimaCarla Andreia AbreuFernanda G De FeliceAntonio GalinaRosalia Mendez-OteroSergio T FerreiraPublished in: Stem cell research & therapy (2019)
hMSC-EVs protected hippocampal neurons from damage induced by AβOs, and this was related to the transfer of enzymatically active catalase contained in EVs. Results suggest that hMSC-EVs should be further explored as a cell-free therapeutic approach to prevent neuronal damage in Alzheimer's disease.