Unsolved mystery of Fas: mononuclear cells may have trouble dying in patients with Sjögren's syndrome.

Irena Lindrova Martina Kolackova Tereza Švadláková Radka VankovaMarcela ChmelarovaMichaela Rosecka Eva Jozifkova Martin Sembera Jan Krejsek Radovan Slezak

Published in: BMC immunology (2023)

had upregulated Fas in Sjögren's syndrome. However, the rate of apoptosis based on Annexin V staining and the Bcl-2/Bax expression was not observed in mononuclear cells. We suspect a functional role of abnormal levels of Fas and FasL which has not been cleared yet.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell death
palliative care
signaling pathway
disease activity
systemic lupus erythematosus
binding protein