Login / Signup

Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Renata L MarkmanLiana P WebberCarlos H V Nascimento FilhoLeonardo A ReisPablo A VargasMarcio A LopesVirgilio ZanellaManoela D MartinsCristiane H SquarizeRogerio de Moraes Castilho
Published in: Cellular oncology (Dordrecht) (2018)
Our findings indicate that bromodomain-mediated gene regulation constitutes an epigenetic mechanism that is deregulated in MEC cells and that the use of BET inhibitors may serve as a feasible therapeutic strategy to manage MECs.
Keyphrases
  • dna methylation
  • induced apoptosis
  • cell cycle arrest
  • gene expression
  • cell death
  • cell proliferation
  • pi k akt