Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.
Renata L MarkmanLiana P WebberCarlos H V Nascimento FilhoLeonardo A ReisPablo A VargasMarcio A LopesVirgilio ZanellaManoela D MartinsCristiane H SquarizeRogerio de Moraes CastilhoPublished in: Cellular oncology (Dordrecht) (2018)
Our findings indicate that bromodomain-mediated gene regulation constitutes an epigenetic mechanism that is deregulated in MEC cells and that the use of BET inhibitors may serve as a feasible therapeutic strategy to manage MECs.