Login / Signup

Proteomic profile of the acquired enamel pellicle of professional wine tasters with erosive tooth wear.

Natália Caldeira SilvaTalita Mendes Oliveira VenturaBethania Paludo OliveiraNicole Marchioro Dos SantosMarília Afonso Rabelo BuzalafMarília Afonso Rabelo BuzalafJonas de Almeida Rodrigues
Published in: European journal of oral sciences (2021)
The aim of this study was to compare the acquired enamel pellicle protein profile of professional wine tasters with mild and moderate erosive tooth wear. Twelve professional wine tasters participated (3 from a low tooth wear group; 9 from a high tooth wear group). Acquired enamel pellicle samples were collected and processed for proteomic analysis (nLC-ESI-MS/MS). The acquired enamel pellicle proteomic profile was different between the groups. The proteins found exclusively in the low tooth wear group were histatins 1 and 3 and mucins 7 and 21. When comparing the wear groups, proteins with higher levels in the low tooth wear group included neutrophil defensins (1 and 3), lysozyme C, lysozyme, myeloperoxidase, and squalene monooxygenase. In conclusion, the findings indicate that the proteins found at higher levels in the low tooth wear group and proteins exclusively found in the low tooth wear group might be protective and, therefore, could be good candidates for further studies regarding their potential to be added to dental products to protect professional wine tasters from extrinsic erosive tooth wear.
Keyphrases
  • ms ms
  • high resolution
  • small molecule
  • high intensity
  • label free
  • high performance liquid chromatography