Protective role of cytochrome c oxidase 5A (COX5A) against mitochondrial disorder and oxidative stress in VSMC phenotypic modulation and neointima formation.

Haijing GuanJingwen SunXiuying LiangWenjuan Yao

Published in: Current vascular pharmacology (2023)

The present study demonstrated that COX5A protects VSMCs against phenotypic modulation by improving mitochondrial respiratory function and attenuating mitochondrial damage, as well as reducing oxidative stress, thereby preventing neointima formation.

Keyphrases

oxidative stress
diabetic rats
ischemia reperfusion injury
dna damage
induced apoptosis
smooth muscle
vascular smooth muscle cells
signaling pathway
endoplasmic reticulum stress
respiratory tract