Elevated C-Reactive Protein in Older Men with Chronic Pain: Association with Plasma Amyloid Levels and Hippocampal Volume.
Tyler R BellCarol E FranzKatherine J BangenMc Kenna E WilliamsLisa T EylerImanuel LermanChristine Fennema-NotestineOlivia K PuckettStephen M DorrosMatthew S PanizzonRahul C PearceDonald J HaglerMichael J LyonsJeremy A ElmanWilliam S KremenPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2024)
Chronic pain was associated with higher plasma Aβ, especially when hs-CRP was also elevated. Higher hs-CRP and Aβ levels were both related to smaller hippocampal volumes. Chronic pain, when accompanied by systemic inflammation, may elevate risk of neurodegeneration in AD-vulnerable regions.