Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe.
Ning ZhuGe XuRongchen WangTianli ZhuJiahui TanXianfeng GuChunchang ZhaoPublished in: Chemical communications (Cambridge, England) (2021)
An activatable and mitochondrial-targetable fluorescent probe was developed. This designed probe showed ratiometric fluorescence and light-up near-infrared emission responsiveness to nitroreductase, achieving precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity.