Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats.
Nikita N BurkeYan LiDaniel R DeaverDavid P FinnMichelle RocheDavid J EyermanConnie SanchezJohn P KellyPublished in: Journal of psychopharmacology (Oxford, England) (2019)
Chronic treatment of buprenorphine alone or buprenorphine plus samidorphan is effective in reversing behavioural deficits in distinct non-clinical paradigms. These non-clinical results complement the antidepressant effect of this combination observed in clinical studies.