Deep DNA sequencing of MGMT, TP53 and AGT in Mexican astrocytoma patients identifies an excess of genetic variants in women and a predictive biomarker.
José Alberto Carlos-EscalanteSonia Iliana Mejía-PérezErnesto Soto-ReyesLissania Guerra-CalderasBernardo Cacho-DíazKarla Torres-ArcigaMichel Montalvo-CasimiroRodrigo González-BarriosNancy Reynoso NoverónMiguel Ruiz de la CruzClara Estela Díaz-VelásquezSilvia Vidal-MillánRosa Maria ÁlvarezThalía Estefanía Sánchez-CorreaClaudio Hiram Pech-CervantesJosé Antonio Soria-LucioAreli Pérez-CastilloAna María SalazarCristian Arriaga-CanonFelipe Vaca PaniaguaAliesha González-ArenasPatricia Ostrosky-WegmanAlejandro Mohar BetancourtLuis Alonso Herrera-MontalvoTeresa CoronaTalia Wegman-OstroskyPublished in: Journal of neuro-oncology (2022)
The occurrence of AGT variants only in women expands our knowledge about the molecular differences in astrocytoma between men and women. The increased prevalence of AGT and MGMT variants in the discovery cohort also points towards possible distinctions in the molecular landscape of astrocytoma among populations. Our findings warrant further study.
Keyphrases
- polycystic ovary syndrome
- end stage renal disease
- copy number
- single molecule
- ejection fraction
- newly diagnosed
- chronic kidney disease
- risk assessment
- healthcare
- single cell
- small molecule
- prognostic factors
- genome wide
- risk factors
- cervical cancer screening
- high throughput
- type diabetes
- skeletal muscle
- cell free
- patient reported outcomes
- adipose tissue
- genetic diversity