Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas.

Alexandro J MartagónOmar Yaxmehen Bello-ChavollaOlimpia Arellano-CamposPaloma Almeda-ValdesGeoffrey A WalfordIvette Cruz-BautistaDonají V Gómez-VelascoRoopa MehtaLiliana Muñoz-HernándezMagdalena Sevilla-GonzálezTannia L Viveros-RuizMaría Luisa Ordoñez-SánchezRosario Rodríguez-GuillenJose C FlorezMaría Teresa Tusié-LunaCarlos Alberto Aguilar-Salinasnull null

Published in: Diabetes care (2018)

Carriers of variant p.E508K in HNF1A have a reduced insulin response rather than the increased sensitivity to sulfonylureas seen in patients with MODY3.

Keyphrases

nuclear factor
type diabetes
metabolic syndrome
toll like receptor
adipose tissue
immune response
inflammatory response
insulin resistance
weight loss