Comparison of photopic negative response measurements in the time and time-frequency domains.

Although each PhNR definition has advantages and disadvantages, all three metrics provide similar estimates of the PhNR. Intra-subject CVs, however, were relatively high for measurements made at 72 ms, indicating that definitions based on a fixed time point may introduce variability. The substantial decrease in intra-subject variation after normalization by the sum of the PhNR and b-wave amplitudes may be advantageous under some conditions.