The VEGF-Hypoxia Signature Is Upregulated in Basal-like Breast Tumors from Women of African Ancestry and Associated with Poor Outcomes in Breast Cancer.
Yoo Jane HanSiyao LiuAshley HardemanPadma Sheila RajagopalJeffrey MuellerGalina F KhramtsovaAyodele SanniMustapha A AjaniWendy ClaytonIan W HurleyToshio F YoshimatsuYonglan ZhengJoel S ParkerCharles M PerouOlufunmilayo I OlopadePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
These data provide further evidence for breast cancer heterogeneity across diverse populations and molecular subtypes. Interventions selectively targeting VEGF-hypoxia and the immune microenvironment have the potential to improve overall survival in aggressive breast cancers that disproportionately impact Black women in the African Diaspora.
Keyphrases
- endothelial cells
- breast cancer risk
- polycystic ovary syndrome
- vascular endothelial growth factor
- pregnancy outcomes
- stem cells
- cervical cancer screening
- physical activity
- single cell
- electronic health record
- big data
- type diabetes
- pregnant women
- cancer therapy
- insulin resistance
- young adults
- risk assessment
- drug delivery
- skeletal muscle
- genome wide association study