Neuroprotective effect of the RNS60 in a mouse model of transient focal cerebral ischemia.

Gloria Patricia Baena-CaldasJie LiLina PedrazaSupurna GhoshAndreas KalmesFrank C BaroneHerman MorenoA Iván Hernández

Published in: PloS one (2024)

RNS60-treated mice exhibit significant protection of brain tissue and improved neurobehavioral functioning after tMCAo-stroke. Additional work is required to determine mechanisms, time-window of dosing, and multiple dosing volumes durations to support clinical stroke research.

Keyphrases

cerebral ischemia
subarachnoid hemorrhage
blood brain barrier
brain injury
mouse model
atrial fibrillation
high fat diet induced
type diabetes
metabolic syndrome
insulin resistance
adipose tissue