IL-13 is a central mediator of chemical-induced airway hyperreactivity in mice.

Fien C DevosLore PollarisJonathan CremerSven SeysTomoaki HoshinoJan CeuppensKarel TalaveraBenoit NemeryPeter H M HoetJeroen A J Vanoirbeek

Published in: PloS one (2017)

We conclude that IL-13 plays a critical role in the effector phase of chemical-induced, immune-mediated AHR. This implicates that anti-IL-13 treatment could have a beneficial effect in patients with this asthma phenotype.

Keyphrases

high glucose
diabetic rats
chronic obstructive pulmonary disease
drug induced
dendritic cells
oxidative stress
endothelial cells
metabolic syndrome
cystic fibrosis
skeletal muscle
allergic rhinitis