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COVID-19 presenting as acute generalized exanthematous pustulosis associated with multiorgan dysfunction in a 44-year-old female patient.

Nicolás Ariza OrdoñezValeria Gomez SepulvedaLina Patricia VargasJulian Mauricio Moreno
Published in: Revista do Instituto de Medicina Tropical de Sao Paulo (2021)
Acute generalised exanthematous pustulosis (AGEP) is an unusual cutaneous reaction, most often related with a hypersensitivity reaction to commonly used drugs. It is characterized by an abrupt onset of a pustular rash within hours or days after drug exposure and usually resolves spontaneously within 1-2 weeks after drug discontinuation. Some cases associated with systemic involvement and shock have been reported. We present the case of a severe AGEP, manifesting in association with systemic involvement and haemodynamic instability resulting in shock and multiorgan dysfunction in an adult female patient diagnosed with COVID-19 infection. There were no identifiable associated drugs, and the patient was not initiated on antimalarial drugs. Our patient improved rapidly, both hemodynamically and dermatologically with no directed therapy.
Keyphrases
  • drug induced
  • case report
  • liver failure
  • sars cov
  • coronavirus disease
  • respiratory failure
  • oxidative stress
  • intensive care unit
  • early onset
  • aortic dissection
  • bone marrow
  • electronic health record