Performance of DNA methylation assays for detection of high-grade cervical intraepithelial neoplasia (CIN2+): a systematic review and meta-analysis.

Helen A KellyYolanda BenaventeMiquel Angel PavonSilvia De SanjosePhilippe MayaudAttila Tibor Lorincz

Published in: British journal of cancer (2019)

DNA methylation is significantly higher in CIN2+ and CIN3+ compared to ≤CIN1. As triage test, DNA methylation has higher specificity than cytology ASCUS+ and higher sensitivity than HPV16/18 genotyping.

Keyphrases

high grade
dna methylation
genome wide
low grade
gene expression
high throughput
emergency department
copy number
loop mediated isothermal amplification