Thyroid hormone treatment improved the response to maximum exercise test and preserved the ventricular geometry in myocardial infarcted rats.
Rayane Brinck TeixeiraAlexsandra ZimmerAlessandra Eifler Guerra GodoyAlexandre Luz de CastroCristina Campos-CarraroAlex Sander da Rosa AraujoAlex Sander da Rosa AraujoPublished in: Experimental physiology (2020)
Left ventricular myocardial infarction (MI) provokes damage in the heart and in other tissues, such as right ventricle and lungs. The present study elucidated whether thyroid hormone treatment (THT) may present positive effects in heart and lungs after MI, and whether or not these effects are similar to those of exercise training (ET). Male Wistar rats were divided into four groups: sham operated (SHAM), infarcted (MI), infarcted + exercise training (MIE), and infarcted + thyroid hormones (MIH). A maximum exercise test, left ventricle echocardiography, pulmonary histology, and oxidative stress in the right ventricle and lung were evaluated. THT and ET both reduced left ventricular dilatation and end-diastolic wall stress indexes to a similar extent. MI accentuated the content of macrophages and inflammatory infiltrate in the lungs, which was partially prevented in the MIH and MIE groups. THT and ET presented similar effects in the heart and lungs, and both improved the performance of the maximum exercise test in infarcted animals.
Keyphrases
- left ventricular
- heart failure
- mitral valve
- oxidative stress
- pulmonary hypertension
- cardiac resynchronization therapy
- high intensity
- acute myocardial infarction
- pulmonary artery
- physical activity
- skeletal muscle
- gene expression
- atrial fibrillation
- resistance training
- computed tomography
- dna damage
- acute coronary syndrome
- clinical trial
- ischemia reperfusion injury
- congenital heart disease
- signaling pathway
- aortic valve