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Induction cyclophosphamide with maintenance immunosuppression in high-risk myasthenia gravis: long-term follow-up and safety profile.

Fiona L Y ChanTodd A HardySameer MalikSudarshini RamanathanD Sean RimintonStephanie Barnes
Published in: Journal of neurology, neurosurgery, and psychiatry (2024)
We describe a large cohort of high-risk MG patients treated with cyclophosphamide in a retrospective single-clinic cohort. We suggest cyclophosphamide should be considered for rapid remission induction, corticosteroid reduction and long-term freedom from recurrent injectable therapies in selected patients, typically those with AChR antibodies.
Keyphrases
  • low dose
  • high dose
  • myasthenia gravis
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • primary care
  • peritoneal dialysis
  • prognostic factors
  • patient reported outcomes