IL-17 drives salivary gland dysfunction via inhibiting TRPC1-mediated calcium movement in Sjögren's syndrome.

Xiao FanWenhan DuXiaoxia ZhuYuan TangLixiong LiuEnyu HuangChong DengCainan LuoMan HanPing ChenLiping DingXiaoping HongLijun WuQuan JiangHejian ZouDongzhou LiuLiwei Lu

Published in: Clinical & translational immunology (2021)

These findings identify a novel function of IL-17 in driving salivary dysfunction during pSS development and may provide a new therapeutic strategy for targeting SG dysfunction in pSS patients.

Keyphrases

oxidative stress
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
rheumatoid arthritis
drug delivery
systemic lupus erythematosus
case report
patient reported outcomes
disease activity
vascular smooth muscle cells