Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization.
Laura ElstGino PhilipsKaat VandermaesenAyse BassezFrancesca LodiManon T A VreeburgOscar R BrouwerRogier SchepersThomas Van BrusselSambit K MohantyAnil V ParwaniLien SpansIsabelle Vanden BemptGerd JacomenMarcella BaldewijnsDiether LambrechtsMaarten AlbersenPublished in: European urology (2024)
Here, we analyzed tissues of penile cancer at the level of individual cells, which helps us understand why patients who harbor a deactivating mutation in the TP53 gene do much worse than patients lacking such a mutation. Such an analysis may help us tailor future therapies based on TP53 gene mutations and human papillomavirus status of these tumors.
Keyphrases
- single cell
- papillary thyroid
- squamous cell
- end stage renal disease
- induced apoptosis
- newly diagnosed
- rna seq
- gene expression
- prostate cancer
- prognostic factors
- cell cycle arrest
- lymph node metastasis
- squamous cell carcinoma
- childhood cancer
- young adults
- radical prostatectomy
- oxidative stress
- patient reported outcomes
- cell proliferation
- current status