Adverse pathophysiological influence of early testosterone therapy on the testes of boys with higher grade sex chromosome aneuploidies (HGAs): a retrospective, cross-sectional study.

Matteo SpazianiC TarantinoC PozzaA AnzuiniF PanimolleG PapiD GianfrilliA LenziA F Radicioni

Published in: Journal of endocrinological investigation (2020)

HGA patients undergoing early testosterone therapy show an earlier and persistent suppression of testicular secretory function. At this age, the testes are still responsive to stimulation with hCG. The selection of patients to be treated must be accompanied by a thorough clinical and hormonal evaluation.

Keyphrases

patients undergoing
newly diagnosed
replacement therapy
prognostic factors
emergency department
cancer therapy
gene expression
type diabetes
adipose tissue
patient reported outcomes
copy number
smoking cessation