A great inspiration for today's vaccination efforts: Biographical sketch of Francisco Xavier Balmis (1753-1819).

The management of the coronavirus disease 2019 pandemic will require huge worldwide vaccination efforts. In this endeavour, healthcare workers face the twofold challenge of reaching remote areas, and persuading people to take the vaccine shots. As it happens, this is nothing new in the history of medicine. Health workers can take inspiration from Francisco Xavier Balmis, a Spanish physician of the 19th century who realised the importance of Jenner's vaccine against smallpox, and led a big successful expedition to administer the vaccines in the Spanish colonial possessions of the Western hemisphere and Asia. This article presents a biographical sketch of Balmis, focusing on his expedition.