Fenretinide treatment accelerates atherosclerosis development in apoE-deficient mice in spite of beneficial metabolic effects.

Marco Busnelli Stefano ManziniFabrizia BonacinaSabina SoldatiSilvia Stella BarbieriPatrizia AmadioLeonardo SandriniFrancesca ArnaboldiElena DonettiReijo LaaksonenSaverio PaltrinieriEugenio ScanzianiGiulia Chiesa

Published in: British journal of pharmacology (2019)

We provide the first evidence that, despite beneficial metabolic effects, fenretinide treatment may enhance the development of atherosclerosis.

Keyphrases

combination therapy
adipose tissue
smoking cessation