Blocking MG53 S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury.

Fengxiang LvYingfan WangDan ShanSile GuoGengjia ChenLi JinWen ZhengHan FengXiaohu ZengShuo ZhangYan Zhang Xinli Hu Rui-Ping Xiao

Published in: Circulation research (2022)

S255 phosphorylation is a biased regulation of MG53 E3 ligase activity. The MG53-S255A mutant provides a promising approach for the treatment of acute myocardial injury, especially in patients with metabolic disorders.

Keyphrases

liver failure
protein kinase
type diabetes
heart failure
respiratory failure
atrial fibrillation
ischemia reperfusion injury
aortic dissection
hepatitis b virus
replacement therapy
subarachnoid hemorrhage