Total Synthesis of Sanctolide A and Formal Synthesis of (2 S )-Sanctolide A.
Gihan C DissanayakeCornelius N NdiJana L MarkleyJames B MartinezPaul R HansonPublished in: The Journal of organic chemistry (2023)
Two synthetic strategies employing phosphate tether-mediated one-pot sequential protocols for the total synthesis of the polyketide nonribosomal peptide macrolide, sanctolide A, and the formal synthesis of the (2 S )-epimer of sanctolide A are reported. In this work, a phosphate tether-mediated one-pot sequential ring-closing metathesis/cross metathesis/substrate-controlled "H 2 "/tether removal approach was developed to accomplish the total synthesis of the natural product sanctolide A.
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