Total Synthesis of Sanctolide A and Formal Synthesis of (2 S )-Sanctolide A.

Two synthetic strategies employing phosphate tether-mediated one-pot sequential protocols for the total synthesis of the polyketide nonribosomal peptide macrolide, sanctolide A, and the formal synthesis of the (2 S )-epimer of sanctolide A are reported. In this work, a phosphate tether-mediated one-pot sequential ring-closing metathesis/cross metathesis/substrate-controlled "H 2 "/tether removal approach was developed to accomplish the total synthesis of the natural product sanctolide A.