Clinical and demographic pattern of chronic granulomatous disease (CGD) from a multicenter perspective: Malaysia's experience over 26 years.
Lokman Mohd NohAmir Hamzah Abdul LatiffIntan Hakimah IsmailRahim Md NoahAsrul Abdul WahabIntan Juliana Abd HamidAdiratna Mat RipenNasuruddin B AbdullahKamarul Azhar RazaliNorzila ZainudinFlorence BakonLong Juan KokAdli AliBilkis Banu SAbd AzizHasniah Abdul LatifSiti Mardhiana MohamadZarina Thasneem ZainudeenIlie Fadzilah HashimIean Hamzah SendutThiyagar NadarajawFaizah Mohamed JamilDavid C E NgMohd Azri Zainal AbidinPublished in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2021)
This study has shown CGD occurs in the major ethnic groups of Malaysia. To the best of our knowledge, this is the first and the largest series of chronic granulomatous disease in South East Asia which may be reflective of similar clinical pattern in the region. C. violaceum infection is associated with a higher mortality in CGD patients in Malaysia. All the CGD patients with C. violaceum infection in this patient series displayed CD4 + (T helper) lymphopenia. We recorded rare clinical manifestation of CGD viz. brain abscess and bronchiectasis.
Keyphrases
- end stage renal disease
- healthcare
- newly diagnosed
- chronic kidney disease
- ejection fraction
- dendritic cells
- risk factors
- interstitial lung disease
- clinical trial
- peritoneal dialysis
- multiple sclerosis
- cardiovascular disease
- coronary artery disease
- brain injury
- blood brain barrier
- cerebral ischemia
- patient reported outcomes
- resting state
- drug induced
- functional connectivity