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Ramipril pretreatment worsened renal injury and survival despite a reduction in renal inflammation in experimentally induced sepsis in mice.

Tzvetanka BondevaKatrin SchindlerClaudia SchindlerGunter Wolf
Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2021)
The data suggest that the effects of ramipril pretreatment are complex. Additional studies including monitoring of hemodynamic parameters are necessary to elucidate the exact mechanism(s) of this observation. In addition, the timing of the ramipril administration could be of importance.
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