IL-37 Attenuates Platelet Activation and Thrombosis Through IL-1R8 Pathway.
Yufei ChenJin HongHaoxuan ZhongYikai ZhaoJian LiWei ShenXinping LuoHaiming ShiLiang HuJunling LiuWen GaoPublished in: Circulation research (2023)
IL-37 directly attenuated platelet activation, thrombus formation, and myocardial injury via IL-1R8 receptor. Accumulated IL-37 in plasma inhibited platelet activation to ameliorate atherothrombosis and infarction expansion, and thus may have therapeutic advantages as potential antiplatelet drugs.
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