FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells.
Doris WongGaëlle AugusteChristian L Lino CardenasAdam W TurnerYixuan ChenYipei SongLijiang MaR Noah PerryRédouane AherrahrouManiselvan KuppusamyChaojie YangJose Verdezoto MosqueraCollin J DubeMohammad Daud KhanMeredith PalmoreJaspreet K KalraMaryam KavousiPatricia A PeyserLjubica MaticUlf HedinAni ManichaikulSwapnil K SonkusareMete CivelekJason C KovacicJohan L M BjorkegrenRajeev MalhotraClint T MillerPublished in: Circulation research (2023)
We show that FHL5 mediates vascular disease risk through transcriptional regulation of downstream vascular remodeling gene programs. These transacting mechanisms may explain a portion of the heritable risk for complex vascular diseases.