Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation.
Laura PergoliLaura CantoneChiara FaveroLaura AngeliciSimona IodiceEva PinatelMirjam HoxhaLaura DioniMarilena LetiziaBenedetta AlbettiLetizia TarantiniFederica RotaPier Alberto BertazziAmedea Silvia TirelliVincenza DoloAndrea CattaneoLuisella VignaCristina BattagliaMichele CarugnoMatteo BonziniAngela Cecilia PesatoriValentina BollatiPublished in: Particle and fibre toxicology (2017)
Research on EVs opens a new path to the investigation of the adverse health effects of air pollution exposure. EVs have the potential to act both as markers of PM susceptibility and as potential molecular mechanism in the chain of events connecting PM exposure to increased coagulation, which is frequently linked to exposure and CVD development.