TLR3/TAK1 signalling regulates rhinovirus-induced interleukin-33 in bronchial smooth muscle cells.

Sangeetha RamuJenny CalvénCharalambos MichaeloudesMandy MenzelHamid AkbarshahiKian Fan ChungLena Uller

Published in: ERJ open research (2020)

RV infection caused higher levels of IL-33 and increased pro-inflammatory and Type 2 cytokine release in BSMCs from patients with non-severe asthma. RV-induced IL-33 expression was mainly regulated by TLR3 and downstream via TAK1. These signalling molecules represent potential therapeutic targets for treating asthma exacerbations.

Keyphrases

mycobacterium tuberculosis
chronic obstructive pulmonary disease
high glucose
toll like receptor
diabetic rats
inflammatory response
immune response
cystic fibrosis
drug induced
lung function
nuclear factor
risk assessment
climate change
air pollution
respiratory tract