Intramyocardial Sprouting Tip Cells Specify Coronary Arterialization.

Elena Cano Jennifer Schwarzkopf Masatoshi Kanda Eric Lars-Helge Lindberg Irene Hollfinger Cristina PogontkeCaroline BraeuningCornelius FischerNorbert HübnerHolger Gerhardt

Published in: Circulation research (2024)

A tip cell-to-artery specification mechanism drives arterialization of the intramyocardial plexus and endocardial tunnels throughout life and is reactivated upon ischemic injury. Differential sprouting programs govern the formation and specification of the venous and arterial coronary plexus.

Keyphrases

coronary artery disease
coronary artery
induced apoptosis
ultrasound guided
cell fate
single cell
cell cycle arrest
public health
cell therapy
endoplasmic reticulum stress
oxidative stress
stem cells
mesenchymal stem cells
cerebral ischemia
cell proliferation