The Pathobiology of Myocardial Recovery and Remission: From Animal Models to Clinical Observations in Heart Failure Patients.
Arick C ParkDouglas L MannPublished in: Methodist DeBakey cardiovascular journal (2024)
Heart failure with reduced left ventricular (LV) ejection fraction (HFrEF) is a morbid and life-threatening disease, arising secondary to abnormalities of cardiac structure and function that lead to adverse LV remodeling. Implementation of medical and device therapies results in significant improvements in patient outcomes that are associated with reverse LV remodeling and improved LV ejection fraction. This review provides an overview of the pathobiology of reverse LV remodeling in animal models and in HFrEF patients. We emphasize the differences between myocardial recovery and remission as well as the fragile nature of maintaining a state of myocardial remission.
Keyphrases
- ejection fraction
- left ventricular
- aortic stenosis
- heart failure
- cardiac resynchronization therapy
- hypertrophic cardiomyopathy
- disease activity
- acute myocardial infarction
- left atrial
- healthcare
- mitral valve
- ulcerative colitis
- primary care
- bariatric surgery
- rheumatoid arthritis
- end stage renal disease
- emergency department
- quality improvement
- acute coronary syndrome
- peritoneal dialysis
- weight loss
- obese patients