(Multivariate)-Metal-Organic Framework for Highly Efficient Antibiotic Capture from Aquatic Environmental Matrices.
Cristina NegroHéctor Martínez Pérez-CejuelaErnesto Francisco Simó-AlfonsoWaseem IqbalJosé Manuel Herrero-MartínezDonatella ArmentanoJesus Ferrando SoriaEmilio PardoPublished in: ACS applied materials & interfaces (2023)
Contamination of aquatic environments by pharmaceuticals used by modern societies has become a serious threat to human beings. Among them, antibiotics are of particular concern due to the risk of creating drug-resistant bacteria and, thus, developing efficient protocols for the capture of this particular type of drug is mandatory. Herein, we report a family of three isoreticular MOFs, derived from natural amino acids, that exhibit high efficiency in the removal of a mixture of four distinct families of antibiotics, such as fluoroquinolones, penicillins, lincomycins, and cephalosporins, as solid-phase extraction (SPE) sorbents. In particular, a multivariate (MTV)-MOF, prepared using equal percentages of amino acids l-serine and l-methionine, also exhibits outstanding recyclability, surpassing the benchmark material activated carbon. The good removal performance of the MTV-MOF was rationalized by means of single-crystal X-ray diffraction. These results highlight the situation of MOFs as a real and promising alternative for the capture of antibiotics from environmental matrices, especially wastewater streams.
Keyphrases
- metal organic framework
- solid phase extraction
- drug resistant
- amino acid
- highly efficient
- high efficiency
- risk assessment
- liquid chromatography tandem mass spectrometry
- human health
- high performance liquid chromatography
- molecularly imprinted
- multidrug resistant
- simultaneous determination
- tandem mass spectrometry
- gas chromatography mass spectrometry
- acinetobacter baumannii
- liquid chromatography
- endothelial cells
- ultra high performance liquid chromatography
- gas chromatography
- data analysis
- wastewater treatment
- ms ms
- heavy metals
- climate change
- life cycle
- adverse drug
- mass spectrometry
- computed tomography
- protein kinase
- pseudomonas aeruginosa
- electronic health record
- contrast enhanced