Unveiling Liquid Gold: Lymph as an HPV Marker in OPSCC to guide treatment decisions.

Distinguishing low versus high-risk HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) is pivotal for tailoring treatment. Liquid biopsy, measuring cell-free HPV-DNA in serum and saliva, assesses treatment response and early-recurrence risk. Postoperative lymphatic fluid, may better guide future adjuvant therapy decisions due to its proximity to primary lesions and lymph nodes.