Rapid Eye Movement Sleep, Neurodegeneration, and Amyloid Deposition in Aging.
Claire AndréPierre ChampetierStéphane RehelElizabeth KuhnEdelweiss TouronValentin OurryBrigitte LandeauGwendoline Le DuFlorence MézengeShailendra SegobinVincent de la SayetteDenis VivienGaëlle ChételatGéraldine Rauchsnull nullPublished in: Annals of neurology (2023)
These results suggest that alterations of REM sleep microstructure are associated with greater neurodegeneration and neocortical amyloid deposition in older adults. Further studies are warranted to replicate these findings, and determine whether older adults exhibiting REM sleep alterations are more at risk of cognitive decline and belonging to the Alzheimer's continuum. ANN NEUROL 2023.