Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis.
Glenda TrujilloAlicia Regueiro-RenChunjian LiuBuqu HuYing SunFarida AhangariVitoria FioriniGenta IshikawaKaram Al JumailyJohad KhouryJohn McGovernChris J LeeXue Yan PengTaylor PivarnikHuanxing SunAnjali WaliaSamuel WooSheeline YuDanielle E Antin-OzerkisMaor SaulerNaftali KaminskiErica L HerzogChangwan RyuPublished in: American journal of respiratory and critical care medicine (2024)
In this novel study, we found that direct TLR9 inhibition mitigates fibroproliferative responses in preclinical models of pulmonary fibrosis. Our work demonstrates the therapeutic potential of direct TLR9 antagonism in IPF and related fibrotic lung diseases.