Non-Adherence is Common in Patients with Apparent Resistant Hypertension: a Systematic Review and Meta-Analysis.
Gabrielle BourqueJulius Vladimir IlinMarcel RuzickaGregory L HundemerRisa ShorrSwapnil S HiremathPublished in: American journal of hypertension (2023)
Indirect methods (pill counts or questionnaires) are insufficient for diagnosis of non-adherence, and report less than half the rates as direct methods (direct observed therapy or urine assays). The overall prevalence of non-adherence in apparent treatment resistant hypertension is extremely high, and necessitates a thorough evaluation of non-adherence in this setting.