Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans.

Darcy E KahnLeigh PerreaultEmily MaciasSimona ZariniSean A NewsomAllison StraussAnna KeregeKathleen HarrisonJanet Snell-BergeonBryan C Bergman

Published in: Diabetologia (2020)

These data reveal previously unknown differences in subcellular IMTG localisation based on metabolic health status and indicate the influence of sarcolemmal and nuclear IMTG on insulin sensitivity. Additionally, these studies suggest saturated IMTG may be uniquely deleterious for muscle insulin sensitivity. Graphical abstract.

Keyphrases

skeletal muscle
electronic health record
genome wide
big data
machine learning
data analysis