Prognostic and Pharmacotypic Heterogeneity of Hyperdiploidy in Childhood ALL.
Shawn H R LeeEmily AshcraftWenjian YangKathryn G RobertsYoshihiro GochoLauren RowlandHiroto InabaSeth E KarolSima JehaKristine R CrewsCharles G MullighanMary V RellingWilliam E EvansCheng ChengJun J YangChing-Hong PuiPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Among different definitions of hyperdiploid ALL, DI is optimal based on independent prognostic impact and also the large proportion of low-risk patients identified. Hyperdiploid ALL exhibited particular sensitivities to asparaginase and mercaptopurine, with chromosome-specific associations.