Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis.

Weijia ChengXiao LiDongling LiuChaochu Cui Xianwei Wang

Published in: Journal of cardiovascular pharmacology and therapeutics (2020)

Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological conditions. Recently, it has been found that EndMT plays an important role in the occurrence and development of fibrotic cardiovascular diseases. In this review, we first summarize the main induction pathways involved in EndMT process. In addition, we discuss the role of EndMT in fibrotic cardiovascular diseases and its potential implication in new therapeutic interventions.

Keyphrases

endothelial cells
cardiovascular disease
bone marrow
stem cells
high glucose
systemic sclerosis
vascular endothelial growth factor
idiopathic pulmonary fibrosis
risk assessment
left ventricular
cell therapy
metabolic syndrome
cardiovascular risk factors
cardiovascular events