Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers.
Felix StickelPhilipp LutzStephan BuchHans Dieter NischalkeInes SilvaVanessa RauschJanett FischerKarl Heinz WeissDaniel GotthardtJonas RosendahlAstrid MarotMona ElamlyMarcin KrawczykMarkus CasperFrank LammertThomas W M BuckleyAndrew McQuillinUlrich SpenglerFlorian EyerArndt VogelSilke MarhenkeJohann von FeldenHenning WegeRohini SharmaStephen R AtkinsonAndre FrankeSophie NehringVincent MoserClemens SchafmayerLaurent SpahrCarolin LacknerKatharina StauferPeter LemmerAlexander LinkLuca Vittorio ValentiJane I GroveGuruprasad P AithalJens-Uwe MarquardtWaleed FateenSteffen ZopfJean-Francois DufourJonel TrebickaChristian DatzPierre DeltenreSebastian MuellerThomas BergJochen HampeMarsha Y MorganPublished in: Hepatology (Baltimore, Md.) (2020)
Carriage of variants in PNPLA3 and HSD17B13 differentially affect the risk for developing advanced alcohol-related liver disease. A genotypic/phenotypic risk score might facilitate earlier diagnosis of HCC in this population.