Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation.
Min Ji ChoDong Gwang LeeJeong Woong LeeByungtae HwangSung-Jin YoonSeon-Jin LeeYoung-Jun ParkSeung-Ho ParkHee Gu LeeYong-Hoon KimChul-Ho LeeJangwook LeeNam-Kyung LeeTae-Su HanHyun-Soo ChoJeong Hee MoonGa Seul LeeKwang-Hee BaeGeum-Sook HwangSang-Hak LeeSang J ChungSungbo ShimJaehyung ChoGoo Taeg OhYoung-Guen KwonJong-Gil ParkJeong-Ki MinPublished in: Cardiovascular research (2022)
The inhibitory effect of PTP4A1 in the dysfunction of vascular endothelial cells could apply to develop a drug for vascular inflammatory diseases including atherosclerosis. This study highlights an alternative as well as an effective therapeutic approach to increase A20 expression, which is an endogenous negative regulator of NF-κB signalling in vascular inflammatory disorders.