Killer cell lectin-like receptor G2 facilitates aggressive phenotypes of gastric cancer cells via dual activation of the ERK1/2 and JAK/STAT pathways.

Yuki ItoMitsuro KandaMasahiro SasaharaChie TanakaDai ShimizuShinichi UmedaYoshikuni InokawaNorifumi HattoriMasamichi HayashiGoro NakayamaYasuhiro Kodera

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)

KLRG2 knockdown attenuated the malignant phenotypes of GC cells via downregulation of JAK/STAT and MAPK-ERK1/2 pathway activity and upregulation of p38 MAPK and p53. Targeted suppression of KLRG2 may serve as a new treatment approach for GC.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell proliferation
cell cycle arrest
single cell
gas chromatography
cell therapy
stem cells
combination therapy
binding protein
high resolution